Kirkuk Journal of Science

Kirkuk Journal of Science

Synthesis of Some N1-Benzyl -6-(thio and alkyl or aryl thio) Uracil derivatives

Author
Abstract
New series of N1-Benzyl -6-(thio derivatives) Uracils have been prepared by reaction of 6-chloro uracil [F3] with benzyl chloride in dimethyl sulphoxide in presence of sodium carbonate to yield N1-Benzyl-6-chloro uracil [F4].Heating of [F4] in ethanol with thiourea and treated with sodium carbonate to yield N1-benzyl-6-marcapto uracil [F5].Alkylation's of compound [F5] with different reagents a new series of uracils were prepared (F7 –F17) .The structures of synthesized compounds were elucidated by using some spectroscopic methods (IR, 1HNMR
Keywords

Volume 8, Issue 4
Autumn 2013
Page 17-25

  • Receive Date 01 December 2013
  • Revise Date 20 December 2013
  • Accept Date 25 December 2013