Synthesis of Some N1-Benzyl -6-(thio and alkyl or aryl thio) Uracil derivatives

Omer Mohammad, Mohsin

doi:10.32894/kujss.2013.87983

Synthesis of Some N1-Benzyl -6-(thio and alkyl or aryl thio) Uracil derivatives

Author

Mohsin Omer Mohammad

10.32894/kujss.2013.87983

Abstract

New series of N1-Benzyl -6-(thio derivatives) Uracils have been prepared by reaction of 6-chloro uracil [F3] with benzyl chloride in dimethyl sulphoxide in presence of sodium carbonate to yield N1-Benzyl-6-chloro uracil [F4].Heating of [F4] in ethanol with thiourea and treated with sodium carbonate to yield N1-benzyl-6-marcapto uracil [F5].Alkylation's of compound [F5] with different reagents a new series of uracils were prepared (F7 –F17) .The structures of synthesized compounds were elucidated by using some spectroscopic methods (IR, 1HNMR

Keywords

Uracil

thiouracil

pyrimidine and

chloro ura

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