Activity of Alanine aminopeptidase and its isoenzyms partially purified from the urine of chronic renal failure patients.

Al-Salihi, Ferah G.; AL-Akabie, Tagreed U.

doi:10.32894/kujss.2008.42148

Activity of Alanine aminopeptidase and its isoenzyms partially purified from the urine of chronic renal failure patients.

Document Type : Research Paper

Authors

Ferah G. Al-Salihi ¹

Tagreed U. AL-Akabie ²

¹ College of Education for women - University of Tikrit

² College of Education - University of Tikrit

10.32894/kujss.2008.42148

Abstract

The study was performed on 50 urine specimens of patients with chronic renal failure ,in addition to the 92 healthy specimens as a control group. The results of the study revealed that Alanine aminopeptidase (AAP) activity of chronic renal failure patients urine shows a highly significant increase (p<0.0001) compared to healthy subjects. Alanine aminopeptidase was purified from urine patients with chronic renal failure and healthy subjects by gel filtration using sephadex G-50, and two isoenzyms of (AAP) I, II were separated from patients urine using anion exchanger (DEAE-sephdexA-50).

Keywords

activity

Alanine

aminopeptidase

its isoenzyms

partially

purified from

urine

chronic renal failure patients

AAP

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