• Register
  • Login
  • العربیة

Kirkuk Journal of Science

  1. Home
  2. Spectrophotometric Determination of Methyldopa in Pure and Pharmaceutical Preparations by the Oxidative Coupling Reaction with 1, 5-Diaminonaphthalene in the Presence of Ammonium Ceric (IV) Nitrate

Current Issue

By Issue

By Author

By Subject

Author Index

Keyword Index

About Journal

Aims and Scope

Editorial Board

Indexing and Abstracting

Related Links

Peer Review Process

News

Authorship

Copyright Policies

Spectrophotometric Determination of Methyldopa in Pure and Pharmaceutical Preparations by the Oxidative Coupling Reaction with 1, 5-Diaminonaphthalene in the Presence of Ammonium Ceric (IV) Nitrate

    Authors

    • Noor Mansoor Ghaib Allah 1
    • Abdul Majeed Khorsheed Ahmed 2
    • Nashwan O. Tapabashi 3

    1 Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq.

    2 Department of Chemistry, College of Education for Pure Science, Kirkuk University, Kirkuk, Iraq

    3 College of Pharmacy, Kirkuk University, Kirkuk, Iraq.

,

Document Type : Research Paper

10.32894/kujss.2022.133098.1060
  • Article Information
  • References
  • Download
  • Export Citation
  • Statistics
  • Share

Abstract

Oxidative coupling reactions are one of the significant methods used in the estimation of certain drugs in pharmaceutical formulations. This study describes the development of a fast and sensitive spectroscopic method considering the determination of trace amounts of methyldopa in an acidic aqueous solution.The adopted method centered on oxidative coupling due to the drug Methyldopa with the reagent 1, 5-diaminonaphthalene in the presence of ceric (IV) ammonium nitrate as oxidizing agent to form a stable blue-colored product, giving the highest absorption at 730 nm. The product was appeared to agree Beer's law within the limits of (5.4 - 39.6) μg /ml, and a value of molar absorptivity equal to 4.79471 ×104 L/ mol. cm. Sandell’s index, 0.0044 μg/ cm2, Relative standard deviation was in the range (0.5942 - 0.9687) %, whereas recovery average and determination factor were 99.908% and 0.9998. The proposed method has been successfully applied in the determination of Methyldopa in its pharmaceutical preparations.

Keywords

  • Methyldopa
  • Spectrophotometric
  • Oxidative Coupling
  • Pharmaceutical

Main Subjects

  • Chemistry
  • XML
  • PDF 422.62 K
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
References
[1] and J. E. Hoover A. Osol, J.T. Anderson. Remington’s pharmaceutical sciences: a treatise on the theory and practice of pharmaceutical sciences, with essential information about pharmaceutical and medicinal agents. Lippincott Williams Wilkins, 1st edition, 2006.
[2] Afsaneh L Sanati and Farnoush Faridbod. Electrochemical determination of methyldopa by graphene quantum dot/1-butyl-3-methylimidazolium hexafluoro phosphate nanocomposite electrode. Int. J. Electrochem. Sci, 12(9):7997–8005, 2017.
[3] L.E. Limbird P.B. Molinoff A.G. Gilman, J.G. Hardman and R.W. Ruddon. The pharmaceutical basis of therapeutics.
[4] C.R. Craig and R. E. Stitzel. Lmodern pharmacology with clinical applications.
[5] Safwan Ashour, Mahmoud Bahbouh, and Mouhammed Khateeb. A novel use of oxidative coupling reactions for determination of some statins (cholesterol-lowering drugs) in pharmaceutical formulations. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 78(3):913–917, 2011.
[6] Hongxiu Dai, Duo Chen, Yuan Li, Pengfei Cao, Nan Wang, and Meng Lin. Voltammetric sensing of dopamine based on a nanoneedle array consisting of nico2s4 hollow core-shells on a nickel foam. Microchimica Acta, 185(3):1–7, 2018.
[7] Paulo Roberto da Silva Ribeiro and Reginaria Morais ´ Duarte. Development and validation of a simple spectrophotometric method for the determination of methyldopa in both bulk and marketed dosage formulations. Brazilian Journal of Pharmaceutical Sciences, 50:573– 582, 2014.
[8] Samy Emara, Tsutomu Masujima, Walaa Zarad, Maha Kamal, Marwa Fouad, and Ramzia El-Bagary. An ecofriendly direct injection hplc method for methyldopa determination in serum by mixed-mode chromatography using a single protein-coated column. Journal of chromatographic science, 53(8):1353–1360, 2015.
[9] Xinhua Lin Jinghua Cheng Liying Huang Hong Yao, Yuan Yuan Sun. Flow-injection chemiluminescence determination of catecholamines based on their enhancing effects on the luminol-potassium periodate system. Luminescence: The journal of Biological and Chemical Luminescence, 21(2):112–7, 2006.
[10] Somayeh Tajik, Hadi Beitollahi, and Pourya Biparva. Methyldopa electrochemical sensor based on a glassy carbon electrode modified with cu/tio2 nanocomposite. Journal of the Serbian Chemical Society, 83(7-8):863– 874, 2018.
[11] Afsaneh L Sanati and Farnoush Faridbod. Electrochemical determination of methyldopa by graphene quantum dot/1-butyl-3-methylimidazolium hexafluoro phosphate nanocomposite electrode. Int. J. Electrochem. Sci, 12(9):7997–8005, 2017.
[12] Sylvain Bernes, Modesto Rodr ` ´ıguez Pastrana, Enrique Huerta Sanchez, and Ren ´ e Guti ´ errez P ´ erez. 1, 5- ´ diaminonaphthalene. Acta Crystallographica Section E: Structure Reports Online, 60(1):o45–o47, 2004.
[13] A.K. Al-Yasir. The effect of some biocontrol agents on some biological.aspects of home fly musca domestica l. (diptera: Muscidae). The Egyptian Journal of Hospital Medicine, 42:33–48, 2011.
[14] Themistocles P Hadjiioannou, Gary D Christian, Michael A Koupparis, and Panayotis E Macheras. Quantitative calculations in pharmaceutical practice and research. VCH New York, 1993.
    • Article View: 240
    • PDF Download: 137
Kirkuk Journal of Science
Volume 17, Issue 4
December 2022
Page 42-49
Files
  • XML
  • PDF 422.62 K
Share
Export Citation
  • RIS
  • EndNote
  • Mendeley
  • BibTeX
  • APA
  • MLA
  • HARVARD
  • VANCOUVER
Statistics
  • Article View: 240
  • PDF Download: 137

APA

Ghaib Allah, N. M., Ahmed, A. M. K., & Tapabashi, N. O. (2022). Spectrophotometric Determination of Methyldopa in Pure and Pharmaceutical Preparations by the Oxidative Coupling Reaction with 1, 5-Diaminonaphthalene in the Presence of Ammonium Ceric (IV) Nitrate. Kirkuk Journal of Science, 17(4), 42-49. doi: 10.32894/kujss.2022.133098.1060

MLA

Noor Mansoor Ghaib Allah; Abdul Majeed Khorsheed Ahmed; Nashwan O. Tapabashi. "Spectrophotometric Determination of Methyldopa in Pure and Pharmaceutical Preparations by the Oxidative Coupling Reaction with 1, 5-Diaminonaphthalene in the Presence of Ammonium Ceric (IV) Nitrate". Kirkuk Journal of Science, 17, 4, 2022, 42-49. doi: 10.32894/kujss.2022.133098.1060

HARVARD

Ghaib Allah, N. M., Ahmed, A. M. K., Tapabashi, N. O. (2022). 'Spectrophotometric Determination of Methyldopa in Pure and Pharmaceutical Preparations by the Oxidative Coupling Reaction with 1, 5-Diaminonaphthalene in the Presence of Ammonium Ceric (IV) Nitrate', Kirkuk Journal of Science, 17(4), pp. 42-49. doi: 10.32894/kujss.2022.133098.1060

VANCOUVER

Ghaib Allah, N. M., Ahmed, A. M. K., Tapabashi, N. O. Spectrophotometric Determination of Methyldopa in Pure and Pharmaceutical Preparations by the Oxidative Coupling Reaction with 1, 5-Diaminonaphthalene in the Presence of Ammonium Ceric (IV) Nitrate. Kirkuk Journal of Science, 2022; 17(4): 42-49. doi: 10.32894/kujss.2022.133098.1060

  • Home
  • About Journal
  • Editorial Board
  • Submit Manuscript
  • Contact Us
  • Glossary
  • Sitemap

News

© Kirkuk University, College of Science

Address: Al-Sayada Area, Kirkuk, Iraq, 36013.

 Google-Maps – Android World | عالم الأندروید

 

Newsletter Subscription

Subscribe to the journal newsletter and receive the latest news and updates

© Journal Management System. Powered by ejournalplus