The current study aimed at knowing the biological efficacy of Ganoderma lucidum mushroom extract anti-oxidation and induced hyperlipidemic using Triton WR1339 and comparing its efficacy with the simvastatin drug. Study at the Animal House in the Department of biology-Faculty of Science of Kirkuk University for the period from 1/5/2017 to 25/5/2017 used 20 rat male Sprague Dawley type. Distributed to 4 groups of 5 rats per group. The control group was treated with a single dose of the normal salin solution, the second group was treated with a single dose within the Intraperatonal (iP) a dose of 300 mg/kg of body weight. The third group was treated with Triton and was dosed with the alcoholic extract of G. Lucidum with a dose of 30 mg/kg bw/day of body weight by Gavage. The fourth group was treated with Triton and dosed with the simvastatin drug at a dose of 0.3 mg/kg body weight. The animals were drugged and the blood was pulled after a period of six days (trial period) showed the results of the biochemical tests that the treatment of rats with Triton material increased morally (p≤0.05) at the total cholesterol level TC, Triglyceride TG, low-density lipoprotein For cholesterol LDL-c, very low density lipoprotein cholesterol VLDL-c, the Athero index and lipid level of the Malondialdhyde MDA. Coupled with the low-density lipoprotein of cholesterol HDL-c, the total capacity of the antioxidant TAC, glutathione GSH and the catalase enzyme CAT compared to a group of control. While the animal dosage of the treatment with Triton and the alcoholic extract of the fungus G.lucidum positive improvement in all the variables mentioned above. The results of this study showed that the fungus extract superior the simvastatin drug at the level of HDL-c as well as at the level of antioxidant balance Oxidation by increasing the level of GSH, TAC and CAT enzyme and reducing MDA fat peroxide. Fungus can be adopted as an effective antioxidant and antihypertensive agent .