Estimation of the Leptin Hormone and Some Biochemical Variables in Patients with Lung Cancer in Kirkuk Province

Document Type : Research Paper

Authors

1 Department of Biology, College of science, Tikrit university, Tikrit, Iraq.

2 Kirkuk Technical Institute, Northern Technical University, Kirkuk, Iraq.

3 Kirkuk health directorate, Kirkuk, Iraq.

Abstract

This study aimed to estimate the level of leptin hormone and some biochemical variables in patients with lung cancer. Twenty five patients with lung cancer and 24 healthy control were enrolled in this study. The results showed a significant decrease in the level of leptin in patients with lung cancer compared to healthy control. In group of patients with lung cancer who had BMI ( 20 – 23 kg/m2 ), ( 24–26 kg/m2 ), ( more than 30 kg/m2 ) the levels of leptin were (1.42 ± 0.54), (4.35 ± 2.19), (8.75 ± 1.2) ng/ml respectively, comparing with the healthy control (4.89 ± 1.29), (6.85 ± 1.49), (9.85 ± 2.62) ng/ml respectively. The results also showed that there was a significant increase in activity of ALT in patients group (30.8 ± 16.4) U/L compared to healthy control (22.8 ± 6.55), while there was no statistically significant differences in the activity of AST in patients group (25.4 ± 8.9) U/L compared to healthy control (27 ± 9.2). There were no statistically significant correlation between leptin level with ALT ( r = -0.104 ) and AST ( r = 0.092 ). AST ( r = 0.092).

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Kirkuk Journal of Science
Volume 14, Issue 2
June 2019
Page 72-82

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History

  • Receive Date: 01 June 2019
  • Revise Date: 20 June 2019
  • Accept Date: 25 June 2019

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