Kirkuk University Journal-Scientific Studies

Abstract

This study aimed to estimate the level of leptin hormone and some biochemical variables in patients with lung cancer. Twenty five patients with lung cancer and 24 healthy control were enrolled in this study. The results showed a significant decrease in the level of leptin in patients with lung cancer compared to healthy control. In group of patients with lung cancer who had BMI ( 20 – 23 kg/m2 ), ( 24–26 kg/m2 ), ( more than 30 kg/m2 ) the levels of leptin were (1.42 ± 0.54), (4.35 ± 2.19), (8.75 ± 1.2) ng/ml respectively, comparing with the healthy control (4.89 ± 1.29), (6.85 ± 1.49), (9.85 ± 2.62) ng/ml respectively. The results also showed that there was a significant increase in activity of ALT in patients group (30.8 ± 16.4) U/L compared to healthy control (22.8 ± 6.55), while there was no statistically significant differences in the activity of AST in patients group (25.4 ± 8.9) U/L compared to healthy control (27 ± 9.2). There were no statistically significant correlation between leptin level with ALT ( r = -0.104 ) and AST ( r = 0.092 ). AST ( r = 0.092).