This research was concerned with a study of the relationship between sorbitol dehydrogenase and hepatitis disease . Blood samples have been drawn from (35) patients with hepatitis and (28) blood samples of healthy as control group ages ranges from (40-65) years. Patients were collected from Al-Salam Hospital in Mosul City under the supervision of specialists Live in Mosul city. Sorbitol dehydrogenase, total serum bilirubin, protein, albumin, globulin and alanine aminotransferase sGPT were measured in blood of these patients. The results showed a significant increase in sorbitol dehydrogenase, sGPT, bilirubin, total serum protein, albumin and globulin levels compared with the control group. There was also study of the relationship between (SDH) activity and the studied parameters in patient group and finding that there are liner correlation coefficient. the results indicated that, there was a positive significant correlation between the activity of enzyme and each of the total protein, albumin, globulin, sGPT, and bilirubin and negative significant corolation between SDH and globulin..