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Spectrophotometric Method for Estimation of Promethazine- HCl in Pharmaceutical Formulation Based on Oxidative Coupling with the Reagent m-Amino Benzoic Acid in Presence of N-Bromosuccinimide.

    Mohammad Salim Abdulaziz Aseen N. Shareef Mohsin Hamza Bakir

Kirkuk University Journal-Scientific Studies, 2019, Volume 14, Issue 4, Pages 236-256
10.32894/kujss.2019.14.4.14

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Abstract

An easy, rapid and sensitive novel spectrophotometric method for estimation of trace amounts of Promethazine-HCl in aqueous solution is described. The method is based on using the oxidative coupling reaction of Promethazine-HCl with m-amino benzoic acid reagent at pH1.2 in the presence of N-bromosuccinimide to produce an intense green color, water soluble, product which exhibit maximum absorbance at 592 nm. Beer's law is obeyed over concentration range of (2-26 µg/ml), with a Ԑ 9.754×〖10〗^3 l/mol.cm, Coefficient determination (R2=0.9991). Sandell̕s index of 0.03289 µg/cm^2, the average recovery is 100.396 %, RSD does not exceed 0.3096 %, LOD of 0.1949 µg/m1 and LOQ of 0.5905 µg/m1. The proposed method was applied successfully for determination of PMZH in its pharmaceutical formulations..
Keywords:
    Mohammad Salim Abdulaziz Aseen N Shareef Mohsin Hamza Bakir
Main Subjects:
  • BioPhysics
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(2019). Spectrophotometric Method for Estimation of Promethazine- HCl in Pharmaceutical Formulation Based on Oxidative Coupling with the Reagent m-Amino Benzoic Acid in Presence of N-Bromosuccinimide.. Kirkuk University Journal-Scientific Studies, 14(4), 236-256. doi: 10.32894/kujss.2019.14.4.14
Mohammad Salim Abdulaziz; Aseen N. Shareef; Mohsin Hamza Bakir. "Spectrophotometric Method for Estimation of Promethazine- HCl in Pharmaceutical Formulation Based on Oxidative Coupling with the Reagent m-Amino Benzoic Acid in Presence of N-Bromosuccinimide.". Kirkuk University Journal-Scientific Studies, 14, 4, 2019, 236-256. doi: 10.32894/kujss.2019.14.4.14
(2019). 'Spectrophotometric Method for Estimation of Promethazine- HCl in Pharmaceutical Formulation Based on Oxidative Coupling with the Reagent m-Amino Benzoic Acid in Presence of N-Bromosuccinimide.', Kirkuk University Journal-Scientific Studies, 14(4), pp. 236-256. doi: 10.32894/kujss.2019.14.4.14
Spectrophotometric Method for Estimation of Promethazine- HCl in Pharmaceutical Formulation Based on Oxidative Coupling with the Reagent m-Amino Benzoic Acid in Presence of N-Bromosuccinimide.. Kirkuk University Journal-Scientific Studies, 2019; 14(4): 236-256. doi: 10.32894/kujss.2019.14.4.14
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