Synthesis and Identification of Some New Thiazole Derivatives which Derived from Pyrazoline Compounds and Evaluation the Antibacterial Activity of Some of them

Al-kadhimi, Ahmed A. H.; Mohammed, Mohsin Omar; Qasim, Ghazwan Thamir

doi:10.32894/kujss.2019.14.4.4

Synthesis and Identification of Some New Thiazole Derivatives which Derived from Pyrazoline Compounds and Evaluation the Antibacterial Activity of Some of them

Document Type : Research Paper

Authors

Ahmed A. H. Al-kadhimi ¹

Mohsin Omar Mohammed ²

Ghazwan Thamir Qasim ²

¹ Department of Chemistry, College of Science, Kirkuk University, Kirkuk, Iraq.

² Department of Chemistry, Collage of Science, Kirkuk University, Kirkuk, Iraq.

10.32894/kujss.2019.14.4.4

Abstract

In this study some new derivatives of thiazole compounds were successfully prepared in two steps with high yields. The first step included a synthesis of a new series of pyrazoline (1a-1i) using a one-pot three components reaction. The reaction between (acetophenone4-nitroacetophenone), different substituted benzaldehyde compounds and thiosemicarbazide in absolute ethanol as a solvent with heating at reflux provided the new series of pyrazoline derivatives in a short reaction times. In the second step, the pyrazoline compounds (1a-1i) refluxed with 4-bromophenacyl bromide in absolute ethanol to produce thiazole compounds (2a-2i) in high yields. The Infra-red technique (FT-IR) was used to identify the synthesised compounds and the proton Nuclear Magnetic Resonance technique (1H-NMR) was used to identify som of them. .

Keywords

Thiazole

Pyrazoline

One

pot reaction

antibacterial activity

Subjects