Kirkuk Journal of Science

Kirkuk Journal of Science

Spectrophotometric Determination of Chlorpromazine Hydrochloride in Pharmaceutical Preparations by Oxidative Coupling reaction.

Document Type : Research Paper

Author
Department of Chemistry, Collage of Science, University of Kirkuk, Kirkuk, Iraq.
Abstract
An easy and simple spectrophotometric method was described for estimating chlorpromazine Hydrochloride drug in aqueous solution. Where The method was adopted on oxidative coupling reaction of the drug with p- nitro aniline in the presence of ceric(IV) ammonium nitrate and hydrochloric acid solution an orange-brown product dye was obtainded with maximum absorption at 525 nm. with moler absorptivity of 9.24×103 l. mol-1. cm-1 and sandell's sensitivity of 0.0385 µg.cm-2 Beer's law is obeyed over the concentration range of (12-46) µg.ml-1. The method was applied successfully for the estimating the drug it's on pure condition or in pharmaceutical preparations (Largactil drug).).
Keywords
Subjects

Volume 13, Issue 3
Summer 2018
Page 23-36

  • Receive Date 01 June 2018
  • Revise Date 20 June 2018
  • Accept Date 25 June 2018