The study included the effect of metformin drug over dose in the liver pregnant non – Diabetic mice with weight ranged (25±2) gm , Orally administration of ( 1.8 , 2.85) mg of drug from (6-18)th day of pregnancy in the morning and once time daily, Drug caused death in half number of animals in 1.8) ) mg concentrate and caused significant increase in liver weight in high concentration 2.85 mg and non significant in low concentration compared with control group ( non treated ) , In addition some histologically changes that included inflammatory cells around damaged blood vessels which increase with high dose caused primary biliary cirrhosis . Other changes include Degeneration , necrosis , Blood vessels damage ,Greenish, Congestion and hemorrhage and fibrosis in the liver of dead mice .
Jamal Jameel,A , Khalid Hamid,A and Nasir Toama,F . (2017). Effect Over Dose of Metformin Drug in Pregnants White Mice Mus Musculus liver . Kirkuk Journal of Science, 12(3), 101-115. doi: 10.32894/kujss.2017.131308
MLA
Jamal Jameel,A , , Khalid Hamid,A , and Nasir Toama,F . "Effect Over Dose of Metformin Drug in Pregnants White Mice Mus Musculus liver ", Kirkuk Journal of Science, 12, 3, 2017, 101-115. doi: 10.32894/kujss.2017.131308
HARVARD
Jamal Jameel A, Khalid Hamid A, Nasir Toama F. (2017). 'Effect Over Dose of Metformin Drug in Pregnants White Mice Mus Musculus liver ', Kirkuk Journal of Science, 12(3), pp. 101-115. doi: 10.32894/kujss.2017.131308
CHICAGO
A Jamal Jameel, A Khalid Hamid and F Nasir Toama, "Effect Over Dose of Metformin Drug in Pregnants White Mice Mus Musculus liver ," Kirkuk Journal of Science, 12 3 (2017): 101-115, doi: 10.32894/kujss.2017.131308
VANCOUVER
Jamal Jameel A, Khalid Hamid A, Nasir Toama F. Effect Over Dose of Metformin Drug in Pregnants White Mice Mus Musculus liver . Kirkuk J. Sci.. 2017;12(3):101-115. doi: 10.32894/kujss.2017.131308
