Spectrophotometric Determination of chlorpromazineHydrochloride in Pharmaceutical Preparations by Oxidative coupling reaction

Mustafa Anwar, Sunbul; Shukur Hussein, Kamaran; Ibrahim Khalil, Ali

doi:10.32894/kujss.2016.131103

Spectrophotometric Determination of chlorpromazineHydrochloride in Pharmaceutical Preparations by Oxidative coupling reaction

Authors

Sunbul Mustafa Anwar

Kamaran Shukur Hussein

Ali Ibrahim Khalil

10.32894/kujss.2016.131103

Abstract

A simple , rapid and sensitive spectrophotometric method for the determination of
microgram amounts of chlorpromazine Hydrochloride drug in aqueous solution is
described. The method is based on the oxidative coupling reaction between chlorpromazine
hydrochloride and N,N – dimethyl-p- phenylenediaminedihydrochloride (DMPD) in the
presence of sodium periodate and hydrochloric acid to form an intense red colored product
with maximum absorption at 525 nm . Beer's law is obeyed over the concentration range
of(4-34) μg.ml-1 with moler absorptivity of 9.239x103 l. mol-1. Cm-1 and sandell's sensitivity
of 0.038 μg.cm-2 . The method does not resort to temperature control or to solvent
extraction . The optimum conditions for all color development are described and the
proposed method has been successfully applied for the determination of chlorpromazine
Hydrochloride in bulk drug and pharmaceutical preparations (Largactil drug).

Keywords

chlorpromazine Hydrochloride

oxidative coupling

spectrophotometric