Abstract
This study included synthesis of Tri [2(4-isobuty phenyl) propionyl ] glycerate afforded
by reaction of Glycerol with Ibuprofen.
The purification of the synthesized derivative was established by (TLC) and column
chromatography while the structure suggesting was confirmed by ( FTIR ، 1H-NMR ) and
the result obtained given good evidence for structure proposed to their compound and using
through the study groups , and take (36) rabbits proximate in the weight and divided into
four groups contain of (9) rabbits . the first group used as acontrol group and the second
group dosed with synthesized compound ( 50 mg/kg ) and the third group dosed with the
solvent used (DMSO) ,and the fourth group dosed with Ibuprofen drugs. After (3)hours
from doses withdrawal blood sample and serum was isolated and Conducted study By
biochemical and enzymatic variables.
Variables included measurement enzyme activity following (Cholinesterase(ChE) were
also measured the concentration of each of the (Total fucose, Fucose bounded
protein,Hexoses bounded protein ) statistical data analysis: revealed signification increase
in the activity of Cholinesterase ، signification increase in level total fucose,Protein
bounded fucose , and signification decrease in level concentration protein bounded
Hexoses ,and signification increase in level concentration , and this study included the
hydrolysis of compound at different pH(acidic and basic) and the results showed that the
compound hydrolyzed at basic medium faster than acidic medium.