Spectrophotometric determination of Chlorpromazine Hydrochloride by oxidative coupling reaction with P-Bromo aniline using Ammonium Ceric Sulphate Dihydrate

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Abstract

A new sensitive spectrophotometric method for the determination of chlorpromazine hydrochloride (CPZH) was developed. The method is based on an oxidative coupling reaction with p-bromoaniline using ammonium ceric sulphate dihydrate as oxidizing agent to produce a violet color, soluble in water, stable product and absorbs at 553 nm. Beer's law was in the linear range 2.5 - 30 μg/ml of CPZH, the molar absorptivity, Sandellʼs sensitivity index and detection limit were 6.5731 × 103 liter. mol-1.cm-1, 0.0541 μg.cm-2 and 0.1361 μg/ml respectively. The RSD value was 1.20 - 1.36 % depending on the concentration. This method was applied successfully to the determination of chlorpromazine hydrochloride in two pharmaceutical formulations (tablets and injection).

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Kirkuk Journal of Science
Volume 11, Issue 1
March 2016
Page 1-19

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History

  • Receive Date: 01 March 2016
  • Revise Date: 20 March 2016
  • Accept Date: 25 March 2016

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