Animal hygiene assessment by spontaneous reactivation and aging kinetics of pesticide compounds

Nkhwa, A.; Al-Kadhi, Najdat Ali; Abass, Mohammed Talat; Abass, Kasim Sakran

doi:10.32894/kujss.2014.96241

Animal hygiene assessment by spontaneous reactivation and aging kinetics of pesticide compounds

Document Type : Research Paper

Authors

¹ School of Medicine, University of Botswana, Republic of Botswana

² Department of Medical laboratory Techniques, Kirkuk Technical College, Foundation of Technical Education Baghdad

³ College of Pharmacy, University of Karbala, Karbala, Iraq

⁴ Department of Basic Nursing Sciences, College of Nursing, University of kirkuk, kirkuk, Iraq

10.32894/kujss.2014.96241

Abstract

The main aims of this paper were to investigate the rate of spontaneous reactivation of butyrylcholinesterase from plasma and serum of farm animals inhibited by the organophosphorus, chlorfenvinphos and trichlorfon. Organophosphorus are among the most toxic of all substances that cause poisoning in farm animals and are the most frequently encountered insecticides, commonly detected in agricultural products, animal-derived foodstuffs, environmental samples and home use and represent a significant potential health risk.The first-order rate constants obtained for spontaneous reactivation (ks) for chlorfenvinphosand trichlorfon for plasma and serum was ranged between 0.012 to 0.811h-1, while aging of phosphorylated butyrylcholinesterase follows the kinetics of a first-order reaction with rate constants aging (ka) ranged between 0.004to 0.653 h-1. Half-time (t1/2) for spontaneous reactivation and aging are higher in trichlorfon compared to chlorfenvinphos and ranged from 1.1 to 28.9h (sheep), 2.1 to 63 h (cattle) and 2.8 to 53.3 h (goat), respectively

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