Abstract
This study involves development of a simple spectrophotometric method and a new flow injection–activated chemiluminescence (FIA-Cl) for the determination of Naproxen (Nap) in Pharmaceutical preparations .
Spectrophotometric method was based on the oxidation of the (Nap) with alkaline potassium permanganate, the reaction is followed spectrometrically by measuring the absorbance of (Nap) at 608 nm .
The reaction time of oxidation of (48 min) method is adopted for determining the drug concentration. The calibration graph was linear in the range of (0.4-2.8)µg.ml-1 with a correlation coefficient of (0.9998), detection limit of (0.281) µg.ml-1, molar absorption coefficient is 2.348×104 L/mol.cm and a relative standard deviation RSD% of (3.12-1.32%). The method of FIA-CL was based on the activation of luminol – cobalt – H2O2 chemiluminescence by (Nap). The linearity is (10-45) µg.ml-1 with detection limit of (5.5)µg.ml-1, and correlation coefficient was (0.9999) n=6 and the relative standard deviation was (1.65-1.12%).
The two methods were applied successfully to determine the content of (NaP) in pharmaceutical preparations with a recovery of 98.99%