Synthesis, Characterization and Biological Activity Evaluation of Some New Azo Derivatives from 2- Amino Benzothiazole and Their Derivatives

K. Ahmed, Abdullmajeed; K. Jebur, Ihmood; Ali Muayad Hamzah, Mohammed

doi:10.32894/kujss.2018.143033

Synthesis, Characterization and Biological Activity Evaluation of Some New Azo Derivatives from 2- Amino Benzothiazole and Their Derivatives

Authors

Abdullmajeed K. Ahmed

Ihmood K. Jebur

Mohammed Ali Muayad Hamzah

10.32894/kujss.2018.143033

Abstract

This study includes synthesis 2-amino benzothiazole and its substitutes (M1-M14) by the reaction of aniline derivatives with KSCN in presence of Br2 and glacial acetic acid then neutralize by concentrated ammonia solution or (by 50% NaOH). The prepared compounds (M3-M5-M6-M11) were used for preparation diazonium salts through reaction with NaNO2 and HCl, at that point diazonium salts were utilized specifically interaction with 4-amino antipyrine and 4-amino-3-hydroxy-1-naphthalene sulphonic acid (in alkaline medium) to produce azo dyes (M15-M22).
These compounds were characterized by their physical properties, spectroscopic information (FT-IR, 1H-NMR, 13C-NMR and CHNS elemental analysis), and also to systematically defining of a few active functional groups for these prepared compounds. The biological activity evaluated for four of prepared compounds towards four kinds of bacteria

Keywords

azo dyes

diazonium salts

benzothiazole

amino antipyrine