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Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city

    Authors

    • Ashna Talaat galaly 1
    • Kalthum Asaaf Maulood 2

    1 Department of Biology, College of Education, Salahaddin University, Erbil, Iraq.

    2 Depatment of Biology, College of Education, University of Salahaddin, Erbil, Iraq.

,

Document Type : Research Paper

10.32894/kujss.2023.137833.1093
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Abstract

Coronavirus infection a new infectious illness brought on by the SARS-COV-2 virus has infected people worldwide as of 2019, a covid-19 disease is associated with hematological and biochemical parameters changes. The present study aimed to evaluate the possible relationship between patient parameters and disease severity. A total of 200 nasopharyngeal swabs and whole blood specimens were collected from individuals suspected of CoV-2 and healthy volunteers as control of both sexes, grouped into four groups:50 patients for each mild, moderate, and severe patients and 50 healthy volunteers. The current study demonstrated that female 82(55%) was more frequently affected than male 68(45%). Hematological parameters including white blood cell count (WBC), granulocyte count, and Red blood cell distribution width (RDW%) (increased significantly p < 0.05, while Lymphocyte count decreased significantly when compared with a control group. Significant differences in hemoglobin concentration, packed cell volume, red blood cell count, and indices of red blood cell count were shown when compared with a control group in both sexes. Regarding biochemical parameters including serum vitamin D, ferritin, D-dimer, procalcitonin (PCT), and liver function tests, serum vitamin D decreased significantly, while serum ferritin, D-dimer, procalcitonin and liver enzymes increased significantly in the covid-19 patients group compared to the control group. According to vitamin D receptor ,gene polymorphism in covid-19 patients genotype Bb was most likely associated and strongly related to getting infected with CoV-2 virus with all the three known stages of infection.Severity of CoV-2 was associated with leukocytosis, lymphopenia and biomarkers are the best predictors of severe CoV-2, with a strong relation of VDR gene polymorphism BsmI with the severity of CoV-2 patients

Keywords

  • SARS-CoV-2
  • Hematological parameter
  • Vitamin D
  • Procalcitonin
  • Vitamin D receptor BsmI

Main Subjects

  • Physiology
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Kirkuk Journal of Science
Volume 18, Issue 2
June 2023
Page 1-14
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APA

galaly, A., & Maulood, K. (2023). Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city. Kirkuk Journal of Science, 18(2), 1-14. doi: 10.32894/kujss.2023.137833.1093

MLA

Ashna Talaat galaly; Kalthum Asaaf Maulood. "Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city". Kirkuk Journal of Science, 18, 2, 2023, 1-14. doi: 10.32894/kujss.2023.137833.1093

HARVARD

galaly, A., Maulood, K. (2023). 'Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city', Kirkuk Journal of Science, 18(2), pp. 1-14. doi: 10.32894/kujss.2023.137833.1093

VANCOUVER

galaly, A., Maulood, K. Determination of some hematological, biochemical parameters and vitamin D receptor gene polymorphism in Kurdish patients with COVID-19 in Erbil city. Kirkuk Journal of Science, 2023; 18(2): 1-14. doi: 10.32894/kujss.2023.137833.1093

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