Spectrophotometric Determination of Promethazine Hydrochloride in Pharmaceutical Formulation by Oxidative Coupling.

Abdulaziz, Mohammad Salim; Bakir, Mohsin Hamza; Shareef, Aseen N.

doi:10.32894/kujss.2019.14.2.7

Spectrophotometric Determination of Promethazine Hydrochloride in Pharmaceutical Formulation by Oxidative Coupling.

Document Type : Research Paper

Authors

Mohammad Salim Abdulaziz

Mohsin Hamza Bakir

Aseen N. Shareef

Department of Chemistry, College of Education for Women, Tikrit University, Tikrit, Iraq.

10.32894/kujss.2019.14.2.7

Abstract

A simple, rapid and sensitive spectrophotometric method for determination of trace amounts of Promethazine hydrochloric in aqueous solution is described. The method is based on using the oxidative coupling reaction of promethazine hydrochloride with 4-amino 2-hydroxy benzoate reagent in acid medium in the presence of N-bromo Succinimide to produce an intense green colour, water soluble, product which exhibit maximum absorbance at 605.5 nm. Beer's law is obeyed over concentration range of (2-32µg/m1), with a molar absorptivity 7540.68 l/mol.cm, Sandel index of 0.04255 µg /cm^2.The average recovery is 100.7703 %, relative standard deviation of 0.3101 to 0.8474 % and D.L of 0.40825 µg/ml..

Keywords

Promethazine hydrochloride

amino

Hydroxy benzoate

Oxidative Coupling

Spectrophotometric determination

Subjects