Acute heart disease patients often go on to develop worsening renal function, termed as a cardiorenal syndrome(CRS). Cardiorenal syndrome is defined as “disorders of the heart and kidneys where by acute or chronic dysfunction in one organ may induce acute or chronic dysfunction of the other. Methods: Omentin-1 were measured in 144 subjects including: 50 samples with cardiorenal syndrome, 25 samples with heart disease, 25 samples with kidney disease and 44 normal healthy . Results: A highly significant increase (p<0.0001) in the levels of omentin-1 with cardiorenal syndrome patients, a highly significant decrease in patients with heart disease and significant decrease (p<0.05) in patients with kidney disease group when compared with control group. There is no significant differences between males and females, while significant increase (p<0.05) in <50 years age groups in patients with heart cardiorenal syndrome and significant decrease (p<0.05) in <50 years age groups in patients with kidney disease when compared with 38-50 years age group. Conclusions Omentin-1 have higher diagnostic validity values in the current study, which may be useful as a diagnostic tool to identify recurrence of the cardiorenal syndromes.