Keywords : acetylenic uracil derivatives and mannich bases

Synthesis of acetylenic mercpto uracil derivatives

Hala M. G. Alzahawy Farah Kh. H. ALjuboory

Kirkuk University Journal-Scientific Studies, 2013, Volume 8, Issue 4, Pages 19-28
DOI: 10.32894/kujss.2013.87985

Research has included the preparation of compounds of acetylenic mercpto uracil compounds. And for the preparation of these derivatives requests 4 - chloro uracil (1) and can be obtained (1) easily from the reaction of 2,4,6 - trichloro Pyrimidin with a mixture of diethyl aniline and phosphorus oxide, trichloro POCl3, after it has been obtained for compound 4 - Mercpto uracil (2) of the reactant compound (1) Thio urea and reflux the mix in the presence of ethanol and then were treated compound (2)with Propagel bromide to obtain a compound (3) 4 - Propyl thiouracil. On the other reactant compound has (1) with a solution of Mercpto acetic acid (SHCH2COOH) in Sodium hydroxide to obtain compound (5) 2,6 - Dihydroxy-4-pyrimidinyl thio acetic acid and then were treated compound (5) with Propagel alcohol to get propaynyl (2,6-dihydroxy-4-pyrimidinyl thio acetate) (6). and for the preparation of Mannich reaction , Acetylenic compounds (3) and (6) were treated with paraformaldehyde in Isopropyl alcohol and the mixture was heated a bit, then added Secondary amine with Copper chloride with continuous heating to obtain derivatives 4a-e and 7a-e.
The purpose of the preparation of these derivatives is to get a new uracil derivatives containing acetylenic amines possible to have a biological effectiveness