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Synthesis and Identification of Some New Thiazole Derivatives which Derived from Pyrazoline Compounds and Evaluation the Antibacterial Activity of Some of them

Ahmed A. H. Al-kadhimi; Mohsin Omar Mohammed; Ghazwan Thamir Qasim

Kirkuk University Journal-Scientific Studies, 2019, Volume 14, Issue 4, Pages 46-62
DOI: 10.32894/kujss.2019.14.4.4

In this study some new derivatives of thiazole compounds were successfully prepared in two steps with high yields. The first step included a synthesis of a new series of pyrazoline (1a-1i) using a one-pot three components reaction. The reaction between (acetophenone4-nitroacetophenone), different substituted benzaldehyde compounds and thiosemicarbazide in absolute ethanol as a solvent with heating at reflux provided the new series of pyrazoline derivatives in a short reaction times. In the second step, the pyrazoline compounds (1a-1i) refluxed with 4-bromophenacyl bromide in absolute ethanol to produce thiazole compounds (2a-2i) in high yields. The Infra-red technique (FT-IR) was used to identify the synthesised compounds and the proton Nuclear Magnetic Resonance technique (1H-NMR) was used to identify som of them. .

Bio-chemical Study on the Effect of 4-amidazoldine-4-One Compound Derived from Naproxen on the Effectiveness of Cholinesterase and Some Biochemical Parameters in Rabbit Serum

Amjed Abbawi Saleh

Kirkuk University Journal-Scientific Studies, 2017, Volume 12, Issue 3, Pages 626-648
DOI: 10.32894/kujss.2017.131460

In this study (4-imidazolidine-4-one) derivative of naproxen was prepared and diagnosed, while the structural formula of this compound was confirmed using the (H-NMR, FTIR,13C-NMR) spectrum. (12) Rabbits of close weights were divided into two groups, the first group is the control group which consists of (4) Rabbits and the second group is the group that was injected with the compound, which was prepared and the number of (8) Rabbits. The first group was given the control group solvent (DMSO), the second group was injected with the compound (AB) and the dose (50 mg / kg) of body weight per rabbit. After 2 hours of the dose, a blood sample was drawn from each rabbit and the plasma was separated. A biochemical and enzymatic study of the variables was carried out. The measured variables included the activity of enzymes (cholinesterase, alanine transaminase, aspartate transaminase) and serum cholesterol concentration. The study proved that the compound has significantly inhibited the cholinesterase activity and can be used in the treatment of patients with Alzheimer's disease and increase the amount of neurotransmitter acetylcholine. Inhibiting cholinesterase inhibits the breakdown of the neurotransmitter and thus will perform the stimulation of the nervous system naturally, and effectively the compound did not significantly affect the activity of the enzyme glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, while the cholesterol level in the rabbit serum had a significant effect.

Synthesis and characterization of some new2- mercapto benzimidazole derivative from ortho phenylenediamine

Ihmood kh .jebur; Noaman F.N. Al-hitti

Kirkuk University Journal-Scientific Studies, 2015, Volume 10, Issue 4, Pages 222-239
DOI: 10.32894/kujss.2015.124183

of hydrazones (N3- N10) were synthesized from the reaction of compound (N2) with various substituted benzaldehydes (aceto phenone) gave hydrazone compounds(N3-N10).Substituted compounds(N11-N12) , compound (N13) , compounds(N14-N16) ,compounds (N17-N18),Were synthesized from cyclization of hydrazones (N3- N10) using chloro acetic acid or tri chloro acetic acid or thio glycolic acid or chloro acetyl chloride respectively.
The synthesized compounds were identified according to their physical properties, spectroscopic data (IR and1H- NMR) in addition to systematic identification of some active functional groups in these compounds. This the research includes synthesis of some new derivatives of 2-mercapto benzimidazole (N1), the compound (N1), prepared by reaction of o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then the compound (N1) was treated with hydrazine hydrate in ethanol to give 2-hydrazinobenzimidazole ( N2).A Number